Testosterone to Estradiol Ratio (T/E2) Calculator
Determines the T/E2 ratio as a measure of male health sexual function.
Refer to the text below the tool for more information about the T/E2 ratio.
The testosterone to estradiol ratio, also known as testosterone to estrogen ratio is one of the most commonly determined parameters of male sexual function. The T/E2 ratio uses the testosterone concentration in ng/dL and the estradiol concentration in pg/mL.
| Parameter | Normal values |
| Testosterone | 300-1000 ng/dL |
| Estradiol | 14-55 pg/mL |
| T/E2 | Not defined* |
*Whilst a normal reference range for the T/E2 ratio has not been defined, a value is considered to be acceptable as long as the testosterone and estradiol/estrogen concentrations are within their normal range.
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2. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.
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The T/E2 ratio
The testosterone to estradiol ratio, also known as testosterone to estrogen ratio is one of the most commonly determined parameters of male sexual function. The T/E2 ratio uses the testosterone concentration in ng/dL and the estradiol concentration in pg/mL.
T/E2 = Testosterone / Estradiol
Whilst a normal reference range for the T/E2 ratio has not been defined, a value is considered to be acceptable as long as the testosterone and estradiol/estrogen concentrations are within their normal range.
| Parameter | Normal values |
| Testosterone | 300-1000 ng/dL |
| Estradiol | 14-55 pg/mL |
| T/E2 | Not defined |
The effects and roles of testosterone in male health are well known whilst those of estradiol (modulating libido, erectile function, and spermatogenesis) are less known. Low testosterone and elevated estrogen were found to increase the incidence of erectile dysfunction independently of one another.
Zheng et al. studied the relationship between the T/E2 ratio and chronic heart disease (CHD) on a sample of 55 male CHD patients and 60 healthy age-matched controls. The study found that the balance of the T/E2 ratio has a crucial role in modulating the effect of androgens on CHD in males.
van Koeverden et al. found that low T/E2 ratios in patients with manifest atherosclerotic disease were associated with an increased systemic inflammation and an increased risk of future major adverse cardiac events (MACE). These effects were also stronger in males with elevated BMI so there may be a link to aromatase activity in white fat tissues.
References
van Koeverden ID, de Bakker M, Haitjema S, et al. Testosterone to oestradiol ratio reflects systemic and plaque inflammation and predicts future cardiovascular events in men with severe atherosclerosis. Cardiovasc Res. 2019; 115(2):453-462.
Zheng HY, Li Y, Dai W, Wei CD, Sun KS, Tong YQ. Imbalance of testosterone/estradiol promotes male CHD development. Biomed Mater Eng. 2012; 22(1-3):179-185.
Gong Y, Xiao H, Li C, Bai J, Cheng X, Jin M, Sun B, Lu Y, Shao Y, Tian H. Elevated t/e2 ratio is associated with an increased risk of cerebrovascular disease in elderly men. PLoS One. 2013; 8(4):e61598.
Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. 2016; 18(3):435-40.
Specialty: Endocrinology
System: Endocrine
Article By: Denise Nedea
Published On: July 27, 2020 · 12:00 AM
Last Checked: July 27, 2020
Next Review: July 27, 2025