Progesterone to Estrogen Ratio (Pg/E2) Calculator

Determines the Pg/E2 ratio as a measure of the health of female sexual function.

Refer to the text below the tool for more information about the Pg/E2 ratio.


The progesterone to estrogen ratio is one of the most commonly determined parameters of female sexual function, used in hormonal balance assessment and prediction of outcomes of in vitro fertilization (IVF).


Progesterone to Estrogen Ratio = progesterone in ng/mL / estrogen in ng/mL

Parameter Normal range values
Progesterone (ng/mL) Pre-ovulation: <0.89
Ovulation: ≤ 12
Post-ovulation: 1.8-24
1st trimester: 11-44
2nd trimester: 25-83
3rd trimester: 58-214
Estradiol (pg/mL) Premenopausal women: 30-400
Postmenopausal women: 0-30
Pg/E2 100-500 if E2 within normal luteal phase range (i.e. 1.3-3.3 pg/mL in saliva or 43-180 pg/mL in blood spot)

Progesterone (Pg)
Estrogen (E2)
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The Pg/E2 ratio

The progesterone to estrogen ratio is one of the most commonly determined parameters of female sexual function, used in hormonal balance assessment and prediction of outcomes of in vitro fertilization (IVF).

Note that usually, progesterone concentration is found in ng/mL and the estradiol concentration is measured in pg/mL so a transformation to ng/mL is required for the latter.

  • Progesterone to Estrogen Ratio = Progesterone in ng/mL / Estradiol in ng/mL

The table below summarises the normal range values for the Pg/E2 ratio and parameters involved.

Parameter Normal range values
Progesterone (ng/mL) Pre-ovulation: <0.89
Ovulation: ≤ 12
Post-ovulation: 1.8-24
1st trimester: 11-44
2nd trimester: 25-83
3rd trimester: 58-214
Estradiol (pg/mL) Premenopausal women: 30-400
Postmenopausal women: 0-30
Pg/E2 100-500 if E2 within normal luteal phase range (i.e. 1.3-3.3 pg/mL in saliva or 43-180 pg/mL in blood spot)

The progesterone/estrogen hormonal balance is estimated before in vitro fertilization, either as Pg/E2 or even E2/Pg. It is generally considered that IVF positive outcomes (success of intra cytoplasmic sperm injection) are linked to a high estradiol/progesterone ratio on day of ovulation.

Romero et al. found that a local change in the Pg/E2 ratio occurs during human parturition at term, following a study on amniotic fluid (20 samples drawn in active labour and 20 samples outside of labor). Spontaneous human parturition at term was associated with significantly increased amniotic fluid concentrations of estradiol.

 

References

Gruber I, Just A, Birner M, Lösch A. Serum estradiol/progesterone ratio on day of embryo transfer may predict reproductive outcome following controlled ovarian hyperstimulation and in vitro fertilization. J Exp Clin Assist Reprod. 2007; 4:1.

Romero R, Scoccia B, Mazor M, Wu YK, Benveniste R. Evidence for a local change in the progesterone/estrogen ratio in human parturition at term. Am J Obstet Gynecol. 1988; 159(3):657-660.

Younis JS, Matilsky M, Radin O, Ben-Ami M. Increased progesterone/estradiol ratio in the late follicular phase could be related to low ovarian reserve in in vitro fertilization-embryo transfer cycles with a long gonadotropin-releasing hormone agonist. Fertil Steril. 2001; 76(2):294-299.


Specialty: Endocrinology

System: Endocrine

Article By: Denise Nedea

Published On: July 27, 2020

Last Checked: July 27, 2020

Next Review: July 27, 2025