Mayo Score Disease Activity Index (DAI) for Ulcerative Colitis (Calculator)

The Mayo Score for Ulcerative Colitis standardizes the severity of a patient's ulcerative colitis symptoms, which in turn helps clinicians assess response to treatment and adapt it accordingly.

Please note this is not a tool to diagnose UC, nor to solely decide need for hospital admission or surgical therapy.

The Mayo Score ranges from 0 to 12 with higher scores indicating worse severity. Patient score is in reference to their previous scores to determine change in function.

Often used in clinical trials, evolutions in the Mayo Score may be interpreted as follows:

Remission is defined as total scores of 2 or less with either of four items scoring no more than 1 point.
Mucosal healing is defined as an endoscopic score of 0 or 1.

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Steps on how to print your input & results:

1. Fill in the calculator/tool with your values and/or your answer choices and press Calculate.

2. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.

Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf.

Mayo Score Disease Activity Index (DAI) Explained

The DAI is a useful and straightforward to administer tool that can help clinicians with the management of ulcerative colitis, with respect to changing or stopping medication. Please note this is not a tool to diagnose UC, nor to solely decide need for hospital admission or surgical therapy.

There are four items in the score, each rated from 0 to 3, where 3 means highest severity.

Mayo Score Disease Activity Index (DAI)	Answer choices	Pts
Stool Frequency	Patient reports a normal number of daily stools	0
	One to two more stools than normal	1
	Three to four more stools than normal	2
	Five or more stools than usual	3
Rectal Bleeding*	None	0
	Blood streaks seen in the stool <½ the time	1
	Blood in most stools	2
	Pure blood passed	3
Endoscopic Findings	Normal or inactive colitis seen	0
	Mild colitis: mild friability, erythema, decrease in vascuality	1
	Moderate colitis: friability, marked erythema, vascular pattern absent, erosions seen	2
	Severe colitis: ulcerations and spontaneous bleeding	3
Physician Global Assessment	Normal	0
	Mild colitis	1
	Moderate colitis	2
	Severe colitis	3

*A score of 3 for bleeding required patients to have at least 50% of bowel motions accompanied by visible blood and at least one bowel motion with blood alone.

The Mayo Score ranges from 0 to 12 with higher scores indicating worse severity. Patient score is in reference to their previous scores to determine change in function.

Originally developed in 1987 during a clinical trial by Schroeder et al. for pH dependent 5-ASA (Asacol), the Mayo Score for Ulcerative Colitis standardizes the severity of a patient's ulcerative colitis symptoms, which in turn helps clinicians assess response to treatment and adapt it accordingly.

Often used in clinical trials, evolutions in the Mayo DAI Score may be interpreted as follows:

Remission is defined as total scores of 2 or less with either of four items scoring no more than 1 point.
Mucosal healing is defined as an endoscopic score of 0 or 1.

The score was found to closely correlate with quality of life in the study by Irvine et al.

References

Original reference

Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987; 317(26):1625-9.

Validation

Travis SP, Schnell D, Krzeski P, Abreu MT, Altman DG, Colombel JF, Feagan BG, Hanauer SB, Lichtenstein GR, Marteau PR, Reinisch W, Sands BE, Yacyshyn BR, Schnell P, Bernhardt CA, Mary JY, Sandborn WJ. Reliability and initial validation of the ulcerative colitis endoscopic index of severity. Gastroenterology. 2013; 145(5):987-95.

Other references

Manginot C, Baumann C, Peyrin-Biroulet L. An endoscopic Mayo score of 0 is associated with a lower risk of colectomy than a score of 1 in ulcerative colitis. Gut. 2015; 64(7):1181-2.

Paine ER. Colonoscopic evaluation in ulcerative colitis. Gastroenterol Rep (Oxf). 2014; 2(3):161-8.

Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberg JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008; 14(12):1660-6.

Mayo Score Disease Activity Index (DAI) for Ulcerative Colitis

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Stool Frequency

Rectal Bleeding