Khorana Score Calculator

The Khorana score is a risk model for chemotherapy-associated thrombosis that employs clinical and biochemical characteristics in patients starting chemotherapy and classifies cancer patients in three risk groups (high, intermediate and low).

The score can be applied in patients with solid tumors and lymphomas but not in patients with brain tumors or myelomas. Identifying cancer patients at high risk of VTE may be used in guiding clinician decision-making.

Khorana Score – VTE Risk Stratification

Khorana Score	Risk Group	Rate of VTE at 2.5 months
≥3	High	6.7 - 7.1%
1 - 2	Intermediate	1.8 - 2.0%
0	Low	0.3 - 0.8%

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Steps on how to print your input & results:

1. Fill in the calculator/tool with your values and/or your answer choices and press Calculate.

2. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.

Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf.

About the score

This risk model for screening the risk of chemotherapy associated venous thromboembolism was developed by Khorana et al. in 2008 (on an observational cohort of cancer patients initiating chemotherapy within the United States) and employs baseline clinical and biochemical characteristics:

■ Cancer type*;

■ Pre-Chemotherapy Platelet Count ≥350 x 10⁹/L;

■ Hemoglobin level <10 g/dL or using RBC growth factors;

■ Pre-chemotherapy leukocyte count >11x10⁹/L;

■ BMI ≥35 kg/m².

*The Khorana score can be applied in patients with solid tumors and lymphomas starting chemotherapy but not in patients with brain tumors or myelomas.

The risk score for chemotherapy-associated VTE events classifies patients into low, intermediate, and high risk groups:

Khorana Score	Risk Group	Rate of VTE at 2.5 months
≥3	High	6.7 - 7.1%
1 - 2	Intermediate	1.8 - 2.0%
0	Low	0.3 - 0.8%

This is not a VTE, DVT or PE diagnosis tool but a risk stratification tool for future risk of VTE. Most subsequent validations of the score were completed in outpatient settings with higher risk cancer patients.

References

Khorana Score for VTE Risk

Jump to:

Cancer type

Pre-Chemotherapy Platelet Count ≥350 x 10⁹/L

Hemoglobin level <10 g/dL or using RBC growth factors

Pre-chemotherapy leukocyte count >11x10⁹/L

BMI ≥35 kg/m²

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About the score

References

Original reference

Validation

Other references