Coronary Perfusion Pressure Calculator
Determines the pressure gradient that drives coronary blood pressure, as difference between DBP and left ventricular end diastolic pressure.
Refer to the text below the tool for more information about the parameters concerned and the interpretation of CPP.
Coronary perfusion pressure or simply perfusion pressure, is defined as the pressure gradient that drives coronary blood pressure, contributing to coronary blood flow.
The term is often used in the research around cardiac arrest with values of 15 mmHg being considered cut-off for positive outcome (return of spontaneous circulation ROSC).
Coronary Perfusion Pressure (CPP) = Diastolic Blood Pressure (DBP) - Pulmonary Capillary Wedge Pressure (PCWP)
| Parameter | Normal Low | Normal High |
| Diastolic Blood Pressure (DBP) | 60 mmHg | 90 mmHg |
| Pulmonary Capillary Wedge Pressure (PCWP) | 2 mmHg | 12 mmHg |
| Coronary Perfusion Pressure (CPP) | 58 mmHg | 78 mmHg |
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1. Fill in the calculator/tool with your values and/or your answer choices and press Calculate.
2. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.
Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf.
Coronary Perfusion Pressure Explained
Coronary perfusion pressure or simply perfusion pressure, is defined as the pressure gradient that drives coronary blood pressure, contributing to coronary blood flow. The term is often used in the research around cardiac arrest with values of 15 mmHg being considered cut-off for positive outcome (return of spontaneous circulation ROSC).
Coronary Perfusion Pressure (CPP) = Diastolic Blood Pressure (DBP) - Pulmonary Capillary Wedge Pressure (PCWP)
CPP is based on diastolic pressures because the left ventricular myocardium gets perfused during diastole rather than systole.
| Parameter | Normal Low | Normal High |
| Diastolic Blood Pressure (DBP) | 60 mmHg | 90 mmHg |
| Pulmonary Capillary Wedge Pressure (PCWP) | 2 mmHg | 12 mmHg |
| Coronary Perfusion Pressure (CPP) | 58 mmHg | 78 mmHg |
CPP is the pressure gradient responsible for myocardial perfusion and so, ensure myocardial oxygen delivery. It is a measure of the effectiveness of cardiopulmonary resuscitation (CPR) during cardiac arrest.
Because the rate of myocardial oxygen extraction is the highest of any organ (70-80%) under resting conditions, maintaining CPP is vital. It can be increased by either increasing coronary perfusion pressure or inducing coronary vasodilation.
If coronary perfusion is inadequate, there is an increased risk of myocardial ischemia and ensuing myocardial infarction result.
Coronary perfusion pressure becomes reduced in common cardiac conditions, including heart failure and coronary artery disease, therefore patients suffering from the aforementioned conditions are at a greater risk of myocardial ischemia.
References
Sutton et al. Hemodynamic-directed Cardiopulmonary Resuscitation During In-Hospital Cardiac Arrest. Resuscitation. 2014; 85(8):983-6.
Heward SJ, Widrich J. Coronary Perfusion Pressure. Treasure Island (FL): StatPearls Publishing; 2020 Jan.
Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol. Rev. 2008; 88(3):1009-86.
Goodwill AG, Dick GM, Kiel AM, Tune JD. Regulation of Coronary Blood Flow. Compr Physiol. 2017; 7(2):321-382.
Specialty: Cardiology
System: Cardiovascular
Abbreviation: CPP
Article By: Denise Nedea
Published On: June 15, 2020 · 12:00 AM
Last Checked: June 15, 2020
Next Review: June 15, 2025