Carboplatin AUC Calculator

Estimates the drug dosage in milligrams based on creatinine clearance and target AUC.

In the text below the form there is more information on the formulas used and on target AUC.


The Carboplatin calculator determines the therapy AUC dose based on the Cockcroft Gault equation and on target AUC.

This method also provides useful information about the kidney function because it computes the creatinine clearance rate.


The Cockcroft and Gault equations are:

■ CrCl for serum creatinine in mg/dL = [(140 - age) x Weight in kilograms (x 0.85 if female)] / (Serum Creatinine in mg/dL x 72)

■ CrCl for serum creatinine in µmol/L = [(140 - age) x Weight in kilograms x (1.23 if male or 1.04 if female)] / (Serum Creatinine in µmol/L)

The calculation of the ideal body weight by Devine’s formula:

■ Male = (50 kg if male or 45.5 if female) + (2.3 x (Height in inches - 60))

Carboplatin dose based on the Calvert formula is:

■ Dosage = Target AUC x (GFR + 25)


Patient`s Gender:*
Patient`s Age:*
Patient`s Weight:*
Patient`s Height:*
Serum creatinine:*
Target AUC:*
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Steps on how to print your input & results:

1. Fill in the calculator/tool with your values and/or your answer choices and press Calculate.

2. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. You can further save the PDF or print it.

Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf.


 

Variables and formulas

This tool estimates the total Carboplatin dose (in mg) based on the Cockcroft Gault equation which provides the estimated creatinine clearance level which is then adjusted by the target AUC.

The variables used are:

■ Patient gender – to be used in the Cockcroft Gault equation and in Devine’s formula;

■ Patient age – in years, to be used in the Cockcroft Gault equation;

■ Patient weight – can be input in either lbs or kg;

■ Patient height – can be specified in either ft and in or cm;

■ Serum creatinine – measured in mg/dL or µmol/L;

■ Target AUC – expected values range between 4 and 8 mg/mL/min;

The Cockcroft and Gault equations when serum creatinine is in mg/dL:

CrCl for male = [(140 - age) x Weight in kilograms] / (Serum Creatinine in mg/dL x 72)

CrCl for female = [(140 - age) x Weight in kilograms x 0.85] / (Serum Creatinine in mg/dL x 72)

The Cockcroft and Gault formulas when serum creatinine is in µmol/L:

CrCl for male = [(140 - age) x Weight in kilograms x 1.23] / (Serum Creatinine in µmol/L)

CrCl for female = [(140 - age) x Weight in kilograms x 1.04] / (Serum Creatinine in µmol/L)

The ideal body weight by Devine’s formula:

Male = 50 kg + (2.3 x (Height in inches - 60))

Female = 45.5 kg + (2.3 x (Height in inches - 60))

The ideal weight result is converted in both kg and lbs for convenience, where (1 kg = 2.20462262 lbs).

Carboplatin dose is based on the Calvert formula:

Dosage = Target AUC x (GFR* + 25)

*Where the GFR is provided by the eCrCl.

 

Carboplatin and target AUC

The carboplatin dosage value takes account of the target area concentration versus time curve and estimated GFR. There is another dosing method, that involves body surface area, however, this is not as accurate.

Target AUC values differ depending on the status of the patient:

■ For patients already treated, target AUC should be around 4 – 7 mg/mL/min;

■ For patients without previous treatment target AUC should be around 6 – 8 mg/mL/min.

It is important to note that in some cases with fluctuant serum creatinine, the estimation may not be as exact, thus it won’t lead to an accurate Carboplatin dose either.

 

References

1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16(1):31-41.

2. Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989; 7:1748-1756.

3. Devine BJ. Gentamicin therapy. DICP. 1974; 8:650–5.


App Version: 1.0.1

Coded By: MDApp

Specialty: Nephrology

System: Urinary

Objective: Determination

Type: Calculator

No. Of Variables: 6

Article By: Denise Nedea

Published On: May 26, 2017 · 02:06 PM

Last Checked: May 26, 2017

Next Review: May 26, 2018